Franziska K. Geis

Franziska K. Geis

Department of Biochemistry , USA

Title Of Presentation :
Unintegrated HIV-1 DNAs are loaded with histones and transcriptionally silenced after nuclear entry prior to retroviral integration

Biography

Franziska K. Geis focuses on the early stages in the life cycle of HIV-1. During her PhD she studied the use of retroviral vectors, suitable for gene therapy approaches, to deliver genes into induced pluripotent stem cells. In her postdoctoral work she has concentrated on host control of retrovirus infection. Her recent findings in chromatinization of unintegrated HIV-1 DNAs and the phenomenon of their transcriptional silencing contribute to a better understanding of the HIV-1 life cycle. Importantly, histone-related silencing of extrachromosomal DNA affects not only retroviruses, but also retroviral-based vector approaches and transient transfected plasmid DNA